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1

Structure-Activity Relationships of Strychnine Analogs at Glycine Receptors

Mohsen, Amal M. Y., Heller, Eberhard, Holzgrabe, Ulrike, Jensen, Anders A., Zlotos, Darius P.

Journal:

Chemistry & Biodiversity

Year:

2014

Language:

english

File:

PDF, 169 KB

english, 2014

2

Recent Advances in Melatonin Receptor Ligands

Darius P. Zlotos

Journal:

Archiv der Pharmazie

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

3

N-Acetyl-5-arylalkoxytryptamine Analogs: Probing the Melatonin Receptors for MT1-Selectivity

Christian Markl, William P. Clafshenkel, Mohamed I. Attia, Shalini Sethi, Paula A. Witt-Enderby, Darius P. Zlotos

Journal:

Archiv der Pharmazie

Year:

2011

Language:

english

File:

PDF, 306 KB

english, 2011

4

6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a Novel Pentacyclic Ring System.

Kittisak Sripha, Darius Paul Zlotos

Journal:

Year:

2003

File:

PDF, 100 KB

2003

5

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a Novel Pentacyclic Ring System.

Kittisak Sripha, Darius P. Zlotos, Stefan Buller, Klaus Mohr

Journal:

Year:

2003

File:

PDF, 99 KB

2003

6

Recent Advances in Melatonin Receptor Ligands

Darius P. Zlotos

Journal:

Year:

2005

File:

PDF, 8 KB

2005

7

ChemInform Abstract: A New Synthetic Approach to Pentacyclic Ring, 6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]-8-dihydrodiindole.

Kittisak Sripha, Darius Paul Zlotos, Ulrike Holzgrabe, Somsak Ruchirawat

Journal:

Year:

2012

File:

PDF, 28 KB

2012

8

Stereochemistry of Caracurine V, iso-Caracurine V, Bisnortoxiferine, and Tetrahydrocaracurine V Ring Systems

Darius P. Zlotos

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

9

Aufbau und Konformation der Hexahydro-isochino[2,1-b][2]benzazepine

Werner Meise, Christoph Arth, Darius Zlotos, Martin Jansen, Claus Feldmann

Journal:

European Journal of Organic Chemistry

Year:

1994

File:

PDF, 690 KB

1994

10

Synthese und Konformation von Hexahydro-isochino[3,2-a][2]benzazepinen des B-Homoberbin-Typs

Werner Meise, Darius Zlotos, Martin Jansen, Nicola Zoche

Journal:

European Journal of Organic Chemistry

Year:

1995

File:

PDF, 886 KB

1995

11

6H,13H-Pyrazino[1,2-a;4,5-a′]diindole analogs: Probing the pharmacophore for allosteric ligands of muscarinic M2 receptors

Darius P. Zlotos, Christian Tränkle, Aliaa Abdelrahman, Daniela Gündisch, Krzysztof Radacki, Holger Braunschweig, Klaus Mohr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

12

Synthesis and pharmacological evaluation of 6a,7-dihydro-6H,13H-pyrazino[1,2-a;4,5-a′]diindole analogs as melatonin receptor ligands

Mohamed I. Attia, Justin Julius, Paula A. Witt-Enderby, Darius P. Zlotos

Journal:

Year:

2007

Language:

english

File:

PDF, 238 KB

english, 2007

13

6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha, Darius Paul Zlotos

Journal:

Year:

2003

Language:

english

File:

PDF, 129 KB

english, 2003

14

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

Kittisak Sripha, Darius P. Zlotos, Stefan Buller, Klaus Mohr

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 137 KB

english, 2003

15

Wirkstoffe in der Pipeline. Können wir die Schlaflosigkeit demnächst besser behandeln?

Darius Paul Zlotos

Journal:

Pharmazie in unserer Zeit

Year:

2007

Language:

german

File:

PDF, 149 KB

german, 2007

16

Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands

Christian Markl, Mohamed I. Attia, Justin Julius, Shalini Sethi, Paula A. Witt-Enderby, Darius P. Zlotos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 446 KB

english, 2009

17

Pharmacological characterisation of strychnine and brucine analogues at glycine and α7 nicotinic acetylcholine receptors

Anders A. Jensen, Parviz Gharagozloo, Nigel J.M. Birdsall, Darius P. Zlotos

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

18

A New Synthetic Approach to Pentacyclic Ring, 6,7,14,15-Tetrahydro[1,5]diazocino[1,2-a:6,5-a’]-8-dihydrodiindole

Sripha, Kittisak, Paul Zlotos, Darius, Holzgrabe, UIrike, Ruchirawat, Somsak

Journal:

Year:

2011

Language:

english

File:

PDF, 642 KB

english, 2011

19

Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a?]diindole analogues as melatonin receptor ligands

Attia, Mohamed I., G?cl?, Deniz, Hertlein, Barbara, Julius, Justin, Witt-Enderby, Paula A., Zlotos, Darius P.

Journal:

Organic & Biomolecular Chemistry

Year:

2007

Language:

english

File:

PDF, 275 KB

english, 2007

20

2-[(1,3-Dihydro-2H-isoindol-2-yl)methyl]melatonin – a novel MT2-selective melatonin receptor antagonist

Heckman, David, Attia, Mohamed I., Behnam, Mira A. M., Mohsen, Amal M. Y., Markl, Christian, Julius, Justin, Sethi, Shalini, Witt-Enderby, Paula A., Zlotos, Darius P.

Journal:

Year:

2011

Language:

english

File:

PDF, 152 KB

english, 2011

21

MT 1 and MT 2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential

Zlotos, Darius. P., Jockers, Ralf, Cecon, Erika, Rivara, Silvia, Witt-Enderby, Paula A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.97 MB

english, 2014

22

Bisquaternary Ligands of the Common Allosteric Site of M 2 Acetylcholine Receptors: Search for the Minimum Essential Distances between the Pharmacophoric Elements

Nassif-Makki, Tamer, Tränkle, Christian, Zlotos, Darius, Bejeuhr, Gesine, Cambareri, Antonella, Pfletschinger, Claudia, Kostenis, Evi, Mohr, Klaus, Holzgrabe, Ulrike

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 263 KB

english, 1999

23

iso -Caracurine V, a Novel Unexpected Decomposition Product of Caracurine V

Zlotos, Darius Paul

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 45 KB

english, 2003

24

Probing the Pharmacophore for Allosteric Ligands of Muscarinic M 2 Receptors: SAR and QSAR Studies in a Series of Bisquaternary Salts of Caracurine V and Related Ring Systems

Zlotos, Darius P., Buller, Stefan, Stiefl, Nikolaus, Baumann, Knut, Mohr, Klaus

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

25

2-[(2,3-Dihydro-1 H -indol-1-yl)methyl]melatonin Analogues: A Novel Class of MT 2 -Selective Melatonin Receptor Antagonists

Zlotos, Darius P., Attia, Mohamed I., Julius, Justin, Sethi, Shalini, Witt-Enderby, Paula A.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 307 KB

english, 2009

26

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M 2 Receptors

Zlotos, Darius P., Tränkle, Christian, Holzgrabe, Ulrike, Gündisch, Daniela, Jensen, Anders A.

Journal:

Journal of Natural Products

Year:

2014

Language:

english

File:

PDF, 434 KB

english, 2014

27

Stereochemistry of Caracurine V

Zlotos, Darius Paul

Journal:

Journal of Natural Products

Year:

2000

Language:

english

File:

PDF, 60 KB

english, 2000

28

Pharmacological Characteristics and Binding Modes of Caracurine V Analogues and Related Compounds at the Neuronal α7 Nicotinic Acetylcholine Receptor

Jensen, Anders A., Zlotos, Darius P., Liljefors, Tommy

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 576 KB

english, 2007

29

N1-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors

Journé, Anne-Sophie, Habib, Samy A. M., Dodda, Bala R., Morcos, Mina N. F., Sadek, Mirna S., Tadros, Sarah A. A., Witt-Enderby, Paula A., Jockers, Ralf, Zlotos, Darius P.

Journal:

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

30

Muscarinic receptor agonists and antagonists

Zlotos, Darius P, Bender, Wiebke, Holzgrabe, Ulrike

Journal:

Expert Opinion on Therapeutic Patents

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

31

Recent Advances in Neuromuscular Blocking Agents

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

32

A Novel Synthesis of the Antidepressant Agomelatine

Markl, Christian, Zlotos, Darius

Journal:

Year:

2011

Language:

english

File:

PDF, 88 KB

english, 2011

33

Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT 1 selectivity

Zlotos, Darius P., Riad, Noura M., Osman, Mai B., Dodda, Bala R., Witt-Enderby, Paula A.

Journal:

Year:

2015

Language:

english

File:

PDF, 217 KB

english, 2015

34

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

Behnam, Mira A. M., Graf, Dominik, Bartenschlager, Ralf, Zlotos, Darius P., Klein, Christian D.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.33 MB

english, 2015

35

Synthesis and Conformational Analysis of Hexahydroisoquino[3,2-b][3]benzazepines (iso-B-Homoberbines)

Meise, Werner, Paul Zlotos, Darius

Journal:

Year:

1997

Language:

english

File:

PDF, 540 KB

english, 1997

36

Update on Melatonin Receptors. IUPHAR Review

Jockers, Ralf, Delagrange, Philippe, Dubocovich, Margarita L., Markus, Regina P., Renault, Nicolas, Tosini, Gianluca, Cecon, Erika, Zlotos, Darius Paul

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.62 MB

english, 2016

37

Erratum to: New spectrofluorimetric methods for determination of melatonin in the presence ofN-{2-[1-({3-[2-(acetylamino)ethyl]-5-methoxy-1H-indol-2-yl}methyl)-5-methoxy-1H-indol-3-yl]-ethyl}acetamide: a contaminant in commercial melatonin preparations

Hany W. Darwish,Mohamed I. Attia,Darius P. Zlotos

Journal:

Chemistry Central Journal

Year:

2016

Language:

english

File:

PDF, 801 KB

english, 2016

38

Crystal structure of 5,11-dihydropyrido[2,3- b ][1,4]benzodiazepin-6-one

Riad, Noura M., Zlotos, Darius P., Holzgrabe, Ulrike

Journal:

Acta Crystallographica Section E Crystallographic Communications

Year:

2015

Language:

english

File:

PDF, 289 KB

english, 2015

39

Drug conjugates-an emerging approach to treat breast cancer

Hasan, Mahmud, Leak, Rehana K., Stratford, Robert E., Zlotos, Darius P., Witt-Enderby, Paula A.

Journal:

Pharmacology Research & Perspectives

Year:

2018

Language:

english

File:

PDF, 4.24 MB

english, 2018

40

PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion

Seufert, Sebastian, Coras, Roland, Tränkle, Christian, Zlotos, Darius P., Blümcke, Ingmar, Tatenhorst, Lars, Heneka, Michael T., Hahnen, Eric

Journal:

Year:

2008

Language:

english

File:

PDF, 1.80 MB

english, 2008

41

11-Aminostrychnine and N -(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors

Zlotos, Darius P., Mohsen, Amal M. Y., Mandour, Yasmine M., Marzouk, Mohamed A., Breitinger, Ulrike, Villmann, Carmen, Breitinger, Hans-Georg, Sotriffer, Christoph, Jensen, Anders A., Holzgrabe, Ulrik

Journal:

Journal of Natural Products

Year:

2019

Language:

english

File:

PDF, 1.29 MB

english, 2019

42

Melatonin Receptor Ligands: A PharmacoâChemical Perspective

Boutin, Jean A, WittâEnderly, Paula A., Sotriffer, Christoph, Zlotos, Darius P.

Journal:

Journal of Pineal Research

Year:

2020

File:

PDF, 19.26 MB

2020

43

A multi-stage virtual screening of FDA-approved drugs reveals potential inhibitors of SARS-CoV-2 main protease

Mandour, Yasmine M., Zlotos, Darius P., Alaraby Salem, M.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2020

File:

PDF, 2.35 MB

2020

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